Rresearch Paper on Following stem cell transplantation, chimerism in myeloid malignancies using flubu4 with and without busulfan pharmacokinetics versus bucy

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Title: Following stem cell transplantation, chimerism in myeloid malignancies using flubu4 with and without busulfan pharmacokinetics versus bucy

Abstract: The effects of individualized busulfan dosing in the era of precision medicine are unclear. We performed a retrospective analysis on 78 patients with myeloid malignancies who received busulfan and fludarabine (FluBu4) with or without measuring the drug’s pharmacokinetics (Bu PK), as well as those who received the drug in combination with cyclophosphamide (BuCy). FluBu4 was administered to 55 patients, 21 of whom had their Bu PK measured, and 23 received BuCy. Total donor cell chimerism revealed that, on day 100, 66.7%, 38.2%, and 73.9% of patients in the FluBu4 with PK, FluBu4 with no PK, and BuCy, respectively, maintained 100% donor chimerism (P =.001). By day 100, 23.8%, 52.9%, and 26.1% of patients in the FluBu4 with PK, FluBu4 without PK, and BuCy groups, respectively, had decreasing donor chimerism (P =.04). On day 30, the Bu PK group had fewer patients with less than 95% donor chimerism than FluBu4 PK, FluBu4 with no PK, and BuCy (P =.18). However, this difference was not statistically significant. (P =.11) The survival distributions did not show any statistical significance. Thus, donor chimerism in myeloid malignancies may be affected by personalized drug dosing. Larger retrospective multicenter studies and prospective clinical trials will need to look into this.

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Medicine

Sub Category: Hematology

Writer Experience: 20+ Years

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