Description
Title: Visualization of the Flavivirus-Host Interaction Landscape Using Genome-Wide CRISPR Screens
Abstract: A number of significant human pathogens, including flaviviruses, contribute significantly to morbidity and mortality across the globe. They are obligate intracellular parasites, just like any other virus. Studying the host cellular elements that encourage or inhibit their replication and pathogenesis becomes crucial as a result. Finding them reveals potential targets for antiviral therapeutics because inhibiting the host dependency factors or activating the host restriction factors can stop viral replication and spread in the cell. The technology known as clustered regularly interspaced short palindromic repeats (CRISPR) has made it possible to perform forward genetic screens and create genetic alterations that can be customized in a variety of cell types and organisms. CRISPR technology is a great tool for performing genome-wide screens to systematically identify and characterize viral host dependency factors because of its simplicity, speed, and high reproducibility. Here, we review the discoveries made by various genome-wide CRISPR screens that have improved our knowledge of the interactions between flaviviruses and hosts.
Keywords: genome-wide CRISPR screens; flaviviruses; virus-host interactions
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biology
Writer Experience: 20+ Years
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