Research Paper on Vaginal Microbiota Biofilm-Producing Enterococcus Isolates

Description

Title: Vaginal Microbiota Biofilm-Producing Enterococcus Isolates

Abstract: Background: Despite the availability of current medical interventions, necrotizing fasciitis (NF) is a rapidly progressing inflammatory infection of the soft tissue (also known as the fascia) with a secondary necrosis of the subcutaneous tissues, leading to a systemic inflammatory response syndrome (SIRS), shock, and ultimately death. With a high rate of mortality, the clinical management of this condition is associated with a sizable amount of morbidity. The virulence of the pathogen that is causing the disease, local host immunity, local wound factors, and the use of empirical antibiotics are just a few of the variables that have an impact on the disease’s prognosis. Clinical practice guidelines (CPG), the distribution of the causing microorganism, and the cost-effectiveness of the medication are frequently the foundations for local trends in the prescription of empirical antibiotics. However, there doesn’t seem to be much research on the preferred empirical antibiotic for treating necrotizing fasciitis in a clinical setting. The common causative microorganisms and current prescription trends in two tertiary centers in Central Malaysia will be discussed in this paper. Methods: Retrospective data on patients treated for NF was gathered from two tertiary care hospitals (Hospital Seremban and Hospital Ampang) in Central Malaysia for this cross-sectional study. The five years of retrospective data obtained from the two hospitals allowed for the identification of 420 NF patients. Results: Ampicillin + sulbactam (n = 258; 61.4%), clindamycin (n = 55; 13.1%), and ceftazidime (n = 41; 9.8%) are the top three empirical antibiotics recommended. The choice of antibiotic has a big effect on how NF turns out. Streptococcus spp. (n = 79; 18.8%), Pseudomonas aeruginosa (n = 61; 14.5%), and Staphylococcus spp. (n = 49; 11.7%) are the top three pathogens responsible for NF. Antibiotic-treated patients had a 0.779-times lower chance of having an amputation. Amputation risk was reduced by 0.934 times in patients with lower laboratory risk indicators for necrotizing fasciitis (LRINEC) scores. Conclusions: In this study, ampicillin + sulbactam was the most frequently prescribed empirical antibiotic, followed by clindamycin and ceftazidime. The recommended antibiotics improve the disease’s prognosis by reducing the risk of an amputation. Following surgical debridement, broad-spectrum empirical antibiotics lower the mortality rate of NF.

Keywords: necrotizing fasciitis; antibiotics; microorganism; Gram-positive; Gram-negative

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Antibiotics

Writer Experience: 20+ Years

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