Description
Title: Using the Islet of Langerhans’ Ceramide and Adiponectin Receptors to Treat Diabetes
Abstract: Ceramides are sphingolipids and serve as the main node of the sphingolipid network. As palmitate and other saturated fatty acids are overproduced in obesity, ceramide levels rise and may be harmful to cells. Insulin resistance, endoplasmic reticulum stress, and mitochondrial dysfunction can all be brought on by elevated ceramide levels. Ceramides have been linked to pancreatic islet cell apoptosis in studies over the past few decades, particularly when glucolipotoxic and inflammatory conditions are present. This review summarizes recent developments in our knowledge of ceramides and adiponectin receptor signaling, focusing on their roles in islet cells and the identification of zinc-dependent lipid hydrolase (ceramidase) activity. In order to prevent islet cell loss and treat diabetes, the therapeutic potential of targeting these events is discussed.
Keywords: ceramides; sphingolipid; ceramide synthase; adiponectin; adiponectin receptor; pancreatic islets; beta cell; lipotoxicity; beta cell apoptosis; AdipoRon; AdipoRonPEG5; ceramidase;
zinc; diabetes
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Chemistry
Writer Experience: 20+ Years
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