Description
Title: Using piezoelectric signals to regenerate vascularized bone
Abstract: In Western nations, there is a rising demand for bone substitutes. In place of natural bone taken from people or other animals, bone graft substitutes are intended to give reconstructive surgeons readily available options. The tissue engineering paradigm allows for the creation of biomaterial scaffolds that incorporate bone stem cells to lessen the drawbacks of conventional tissue grafts. However, insufficient neovascularization prevents tissue-engineered bone from being used in clinical settings effectively. A successful regeneration requires new methods to encourage both osteogenesis and vasculogenesis within the scaffolds because bone is a highly vascularized tissue. It has been established that bone and blood vessels are piezoelectric, meaning that mechanical stimulation of these tissues causes localized production of electric signals. Although the precise effects of electric charge generation on various cells are not yet fully understood, a large body of evidence suggests that these cells play important physiological and functional roles. By taking into account various stem cell sources involved with osteogenic and angiogenic potential, this review summarizes the unique contribution of piezoelectricity as a stimulatory signal for bone and vascular tissue regeneration, including osteogenesis, angiogenesis, vascular repair, and tissue engineering. Its goal is to compile the key findings that may enable the development of successful vascularized bone replacements useful in orthopedic and otologic surgery.
Keywords: biomaterials; scaffold; tissue engineering; angiogenesis; osteogenesis; stem cells; mesodermal progenitor cells; orthopedics; otology
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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