Description
Title: Update on Glycine Receptors in Spinal Nociceptive Control
Abstract: One of the primary causes of chronic pain states is decreased inhibitory control of spinal nociception. A well-established rational therapeutic strategy being investigated by several pharmaceutical companies is the restoration of proper synaptic inhibition. The need for site-specific intervention poses a particular challenge because wide-ranging facilitation of inhibition could have negative side effects like sedation, addiction, or impaired motor control. It may be possible to lessen these side effects by specifically targeting glycinergic inhibition, which predominates in the spinal cord and some regions of the hindbrain. The 3 subtype of glycine receptors (GlyRs), which is highly enriched in the superficial layers of the spinal dorsal horn, a critical site of nociceptive processing, may be specifically targeted in order to further focus and improve the tolerability of pharmacological interventions on the nociceptive system. This review offers a current assessment of the physiological characteristics and roles of GlyRs of the 3 subtype as well as the status of related drug discovery initiatives.
Keywords: glycine; GABA; pain; inhibition; spinal cord; dorsal horn; hyperalgesia; allodynia; circuit; mouse
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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