Description
Title: Understanding Breast Cancer Biology and Metabolism Using Magnetic Resonance Imaging (MRI) and MR Spectroscopic Methods
Abstract:Breast cancer is a typical cancer that affects women. It is the second most common reason for a woman to die from cancer. Metabolic reprogramming takes place during the development, invasion, and metastasis of cancer. Functional magnetic resonance (MR) methods, which include a variety of techniques, have demonstrated the potential to illustrate changes in physiological and molecular processes before they manifest anatomically on standard MR imaging. Among these, in vivo proton (1H) MR spectroscopy (MRS) is frequently used to assess elevated choline-containing compounds and distinguish breast cancer from benign diseases. Additionally, the use of hyperpolarized 13C and 31P MRS improved knowledge of phospholipid and glucose metabolism. Through in vitro high resolution NMR spectroscopy and high-resolution magic angle spectroscopy, the metabolic profile of a variety of biological specimens (intact tissues, tissue extracts, and various biofluids such as blood, urine, nipple aspirates, and fine needle aspirates) can also be investigated (HRMAS). By revealing data on additional metabolites beyond those detected by in vivo MRS, such studies can shed more light on the biology and metabolism of cancer. The tumor sub-types were classified through the analysis of numerous NMR spectral data sets using multivariate statistical methods. It demonstrated tremendous potential for the creation of novel therapeutic modalities. Multiparametric MRI techniques have recently been discovered to be useful in quantifying structural, vasculature, diffusion, perfusion, and metabolic abnormalities in vivo in order to better understand the pathophysiology of cancer. This review focuses on how NMR, MRS, and MRI techniques are used to diagnose and track the treatment of breast cancer as well as to better understand the biology of the disease.
Keywords: breast cancer; biology; metabolism; metabolomics; nuclear magnetic resonance (NMR); magnetic resonance imaging (MRI); magnetic resonance spectroscopy (MRS); biomarkers;
therapeutic response
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biology
Writer Experience: 20+ Years
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