Research Paper on Types, grades, and timing of cytopenia in Kenyan CML patients taking imatinib

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Title: Types, grades, and timing of cytopenia in Kenyan CML patients taking imatinib

Abstract: Background. The gold standard for treating all stages of chronic myeloid leukemia that tests positive for the Philadelphia chromosome is imatinib mesylate. Due to drug toxicity, imatinib patients may experience cytopenia. The purpose of this study was to identify the types, grades, and progression of cytopenia in imatinib-treated CML patients at a hospital in Nairobi. Methods. From 2007 to 2015, adult patients under the age of 18 who were being monitored at the Glivec International Patient Access Program (GIPAP) clinic were the subject of a cross-sectional descriptive study. Patients qualified if cytopenia appeared within a year of starting imatinib. From the patients’ charts, clinical and hematologic information was taken, and it was then entered into a study proforma. The analysis used measures of central tendency like mean, median, mode, standard deviation, and variance. Results. Sixty three percent (63.6%) of the 94 patients experienced monocytopenia, while 34% of them experienced anemia, 27.6% had neutropenia, and 8% had thrombocytopenia. The most prevalent bicytopenia, at 12.7%, was anemia combined with neutropenia. Of the 94 patients, only 5 had pancytopenia. Grades 2 and 3 cytopenia constituted the majority. Neutropenia and thrombocytopenia appeared within a year of starting imatinib, while anemia was present at baseline. Neutropenia and thrombocytopenia disappeared within 24–36 months of treatment, while anemia disappeared within the first 12 months of therapy. Conclusion. The most prevalent type of cytopenia was monocytopenia, particularly anemia. *e cytopenia was typically grade 2 and manifested in the majority of patients within 6 months of imatinib start-up. It resolved 24 to 36 months later.

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Medicine

Sub Category: Hematology

Writer Experience: 20+ Years

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