Description
Title: Turmeric’s non-curcuminoids and their potential for anticancer drug delivery formulations and cancer therapy
Abstract: The biological activities of curcuminoids, including their antiulcer, antifibrotic, antiviral, antibacterial, antiprotozoal, antimutagenic, antifertility, antidiabetic, anticoagulant, antivenom, antioxidant, antihypertensive, antihypocholesteremic, and anticancer properties, have been extensively studied over the past few decades. These substances are a vital part of cancer research and are well known as potential anticancer agents due to the perception of low toxicity and cost. The non-curcuminoids, or other bioactive molecules of turmeric, are also as potent as curcuminoids but have received much less attention in research. This review aims to examine the comprehensive potency of non-curcuminoids like turmerones, elemene, furanodiene (FN), bisacurone, germacrone, calebin A (CA), curdione, and cyclocurcumin, as well as their identification, physicochemical properties, and anticancer mechanism. There is also discussion of the clinical research on these curcumin-free compounds, which offers a wealth of evidence in favor of their therapeutic potential. Similar to curcuminoids, these compounds’ limited solubility and bioavailability place restrictions on their potential uses. The encapsulation of non-curcuminoid components in various drug delivery systems, such as co-crystals, solid lipid nanoparticles, liposomes, microspheres, and polar-non-polar sandwich (PNS) technology, is thus credited in this review for helping to overcome their drawbacks and showcasing their ostentatious advantages as anticancer activities.
Keywords: turmeric; curcuminoids; non-curcuminoids; bioactive molecules; anticancer activity
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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