Description
Title: Tissue Engineering Strategies for Treating Avascular Necrosis of the Femoral Head
Abstract: Osteoarthritis of the hip that is symptomatic is frequently brought on by avascular necrosis (AVN) of the femoral head. Hip replacement is a good option for older patients because it restores hip biomechanics and reduces pain, but it comes with risks for children, adolescents, and young adults. significant restrictions on activity and the requirement for numerous revision surgeries with an elevated risk of complications. Since X-rays are not sensitive in the early stages of the disease, early detection of AVN necessitates a high level of suspicion. There are numerous etiologies that could result in to this illness. Trauma is a widely acknowledged cause of AVN in children and adolescents. Developing a clinically effective treatment plan is difficult due to the limited knowledge of the disease’s pathophysiology. Core decompression, vascular grafts, and use of bone-marrow derived stem cells with or without adjuncts, such as bisphosphonates and bone morphogenetic protein (BMP), are surgical techniques to stop the progression of the disease and avoid total hip replacement; however, all of these are only partially effective in the very early stages of the disease. Additionally, these methods frequently only help some patients’ pain and range of motion temporarily and do not predictably stop the disease from progressing. Tissue manipulation A potential method to avoid metallic implants and surgery is to use biomaterials, stem cells, and growth factors in combination. Inducing osteogenic differentiation to regenerate bone while stabilizing the femoral head is possible with structural, bioactive biomaterial platforms. and offer angiogenic cues to concurrently restore the femoral head’s vasculature. In addition, injectable systems that can be administered through a minimally invasive procedure and support the collapsing femoral head mechanically may reduce the need for future surgical interventions. The limitations of current surgical techniques are discussed, along with recent developments in tissue engineering that point to a clinically viable, translational treatment for AVN in the future.
Keywords: avascular necrosis; femoral head; osteonecrosis; tissue engineering; bone
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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