Description
Title: The Wound Repair Roles of Hyaluronan Are Captured to Fuel Breast Cancer Progression
Abstract: Extracellular matrix (ECM) signaling has become an important regulator of the healing of tissue damage as well as the development of illnesses like metastatic cancer. A significant part of the ECM is hyaluronan (HA), which has a dual role in wound healing by sequentially promoting and suppressing inflammation and fibrosis in the event of tissue injury. Tumor cells use these crucial HA microenvironmental functions of response to injury to invade and evade immune detection. In this review, we first go over the many size-dependent functions of HA and emphasize how two of its receptors, CD44 and RHAMM, control the dual signaling of HA in excisional wound healing. The deregulation of HA metabolism in malignant progression is then discussed, along with potential therapeutic uses for HA targeting to better control the spread of breast cancer.
Keywords: hyaluronan; RHAMM; CD44; wound repair; breast cancer
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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