Research Paper on The Structural Dynamics, Interactome, Metabolic Regulation, and Inhibitors of the Mitochondrial HSP90 Paralog TRAP1

Description

Title: The Structural Dynamics, Interactome, Metabolic Regulation, and Inhibitors of the Mitochondrial HSP90 Paralog TRAP1

Abstract: The paralog HSP90 Although TRAP1 has been known for more than 20 years, a thorough understanding of this mitochondrial molecular chaperone’s role is still elusive. Understanding TRAP1’s function in mitochondrial biology is made more challenging by the fact that it is dispensable both in vitro and in vivo. In comparison to eukaryotic HSP90, TRAP1 is more homologous to the bacterial HSP90, HtpG. Without co-chaperones, TRAP1’s distinctive structural characteristics probably control its temperature-sensitive ATPase activity and provide insight into the potential alternate mechanisms governing the chaperone’s nucleotide-dependent cycle in a controlled environment with a physiological temperature of about 50 °C. In addition to mediating the equilibrium between oxidative phosphorylation and glycolysis, TRAP1 also appears to have cytoprotective activity, promote mitochondrial homeostasis, and act as a bioregulator of mitochondrial respiration. Multiple neurodegenerative diseases have been linked to TRAP1 inactivation or loss, and multiple cancers have been linked to elevated TRAP1 expression. As with HSP90, TRAP1 has also been linked to evidence of addiction. The current state of knowledge about this particular HSP90 paralog is outlined in this review, along with the reasons why a deeper comprehension of TRAP1 structure, function, and regulation will likely improve our knowledge of the mechanistic underpinnings of mitochondrial homeostasis.

Keywords: HSP90; TRAP1; molecular chaperone; mitochondria; metabolism; OxPhos; tetramers

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Biomolecules

Writer Experience: 20+ Years

Plagiarism Report: Turnitin Plagiarism Report will be less than 10%

Restriction: Only one author may purchase a single paper. The paper will then indicate that it is out of stock.

What will I get after the purchase?

A turnitin plagiarism report of less than 10% in a pdf file and a full research paper in a word document.

In case you have any questions related to this research paper, please feel free to call/ WhatsApp on +919726999915