Description
Title: The Relationship between Antimicrobial Resistance and Biofilm Formation and Potential Ingenious Bio-Remedial Methods
Abstract: Due to worries in a number of industries, including public health, medicine, and the pharmaceutical industry, biofilm has attracted a lot of attention. The ability of bacteria that produce biofilms to resist drugs is astounding, which increases morbidity and mortality. The healthcare industry is under tremendous financial pressure as a result. Biofilm development is a complicated phenomenon influenced by a number of variables. Insights into the mechanisms to target for the therapy have been gained from numerous attempts to unravel the events of biofilm formation. Targeting pathogens within biofilm is in fact a lucrative endeavor because the biofilm-state renders bacterial pathogens significantly resistant to antibiotics. The pathogen can be eliminated using the currently available medications, which reduces the need for antimicrobial therapy. Plants, animals, and people have all been found to be infected by biofilm formers. There has been a lot of interest in the development of novel approaches to treating and preventing the formation of biofilms, such as bioinformatics tools. It is possible to create cutting-edge anti-biofilm agents, like silver nanoparticles, by using omics techniques like transcriptomics, metabolomics, and proteomics. The anti-biofilm properties of nanoparticles may aid in reducing antimicrobial resistance (AMR). Using mechanistic understanding, virtual screening, and machine learning in silico techniques, this strategy may also be combined to gain a better understanding of biofilm biology and find small molecules that can inhibit important biofilm regulators. The field of research that has been sparked to find workable controls to stop the formation of biofilms is expanding quickly. As a result, the current article discusses the current understanding of biofilm formation, mechanisms underlying antibiotic resistance in bacterial biofilm, and cutting-edge therapeutic approaches to treat infections caused by biofilms.
Keywords: biofilm; AMR; silver nanoparticles; multidrug resistance; extracellular polymeric sub-stances; biofilm control
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biology
Writer Experience: 20+ Years
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