Description
Title: The potential for using specific bone morphogenetic proteins in the diagnosis and treatment of severe asthma
Abstract: Asthma is a chronic, diverse condition of the lower airways that has an inflammatory basis and develops from bronchial obstruction and hyperresponsiveness. The long-term remodeling of the respiratory tract, which causes a total and irreversible obstruction, is one of the more unfavorable processes affecting the airway. The Transforming Growth Factor beta (TGF-b) superfamily, which controls processes in embryonic and post-embryonic development, includes the bone morphogenetic protein (BMP). BMP controls the extracellular matrix’s remodelling and degradation, which is one of the processes involved in rebuilding the bronchial structure in people with severe asthma. This study describes the antagonistic effects of BMP on TGF-b, as well as its ability to reduce inflammation and prevent fibrosis in the respiratory tract. According to the current state of knowledge, additional research is required to determine the therapeutic value of this group of cytokines as potential new markers of remodelling in severe asthma.
Keywords: bone morphogenetic proteins, BMP signalling pathway, inflammation, remodelling, asthma
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Advances in Respiratory Medicine
Writer Experience: 20+ Years
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