Description
Title: The etiopathogenetic of severe asthma and the role of the TGF-SMAD signaling pathway
Abstract: The symptoms of asthma include bronchial hyperresponsiveness and intermittent, cyclical bronchial obstruction. Asthma is a chronic, inflammatory, heterogeneous disease of the lower respiratory tract. One of the cytokines involved in mediating airway inflammation and remodeling is transforming growth factor-beta (TGF-b). TGF-b1 gene expression levels and symptom severity are correlated. A clinically induced moderate-severe or severe course of asthma as well as an earlier and faster disease progression are brought on by changes in the main SMAD signal transmission, overexpression of TGF-b genes, and changes in the transcriptome. Excessive TGF-b secretion and its increased expression in target cells are the results of these changes. Understanding these processes enables clinicians to evaluate patient immune responses, which has an impact on effective disease control and remodeling prevention.
Keywords: transforming growth factor b TGF-b, signalling proteins SMAD, remodelling; severe asthma
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Advances in Respiratory Medicine
Writer Experience: 20+ Years
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