Description
Title: The development of tumor microenvironment on a chip and its prospects
Abstract: Complex microenvironments are necessary for the development of tumors in order for them to grow, invade, and metastasize. Malignant or drug-induced tumors depend critically on their microenvironment. Tumor resistance is emerging as a promising therapeutic target. One emerging platform that enables for quantitative and reproducible characterization of tumor responses with pathophysiological relevance is microengineered physiological systems that can mimic tumor environments. This review focuses on recent developments in engineered tumor microenvironment systems that make it possible to conduct a mechanistic analysis of cancer development and metastasis that has never been done before. We talk about how these microengineered biomimetic approaches for anticancer drug prescreening applications are coming along and what the future holds for them.
Keywords: organ-on-a-chip; microfluidics; in vitro disease models; tumor microenvironment; drug screening; nanomedicine
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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