Description
Title: The Cross Marks the Spot: JmjC Domain-Containing Proteins’ Emerging Role in Myeloid Malignancies
Abstract: As chromatin accessibility, transcription, cell division, and proliferation are all tightly regulated by histone methylation, its disruption can lead to the oncogenic reprogramming of cells. Numerous myeloid malignancies, in particular, exhibit epigenetic dysregulation. Histone demethylases (KDMs), which take away methyl groups from lysines in histone tails and other proteins, are a large and varied group of enzymes. These enzymes are known as jumonji C (JmjC) domain-containing proteins. These demethylases are appealing targets for therapeutic interventions because mounting evidence points to an emerging role for them in myeloid malignancies. In this review, we list the known roles of proteins with Jumonji C (JmjC) domains in myeloid malignancies. We discuss difficulties in comprehending the context-dependent mechanisms of these proteins and consider potential directions for pharmacological therapy in the future.
Keywords: KDM; Jumonji C (JmjC) domain; histone demethylation; leukemia; myelodysplastic syndrome; myeloproliferative neoplasm; targeted therapy
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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