Research Paper on The Biological and Structural Landscape of Cyclic Dipeptides with a Special Emphasis on the Anti-Cancer Proline-Based Scaffold

Description

Title: The Biological and Structural Landscape of Cyclic Dipeptides with a Special Emphasis on the Anti-Cancer Proline-Based Scaffold

Abstract: Diketopiperazines (DKP), the most basic cyclic form of peptide found throughout nature, are unrivaled in their structural and bio-functional diversity. Cyclic dipeptides are also known as these compounds. Due to their distinctive properties, including extra-rigid conformation, high resistance to enzyme degradation, increased cell permeability, and expandable ability to bind a diverse range of targets with better affinity, DKPs, especially those containing proline, have emerged in recent years as biologically pre-validated platforms for drug discovery. Recent developments have demonstrated their enormous potential in the creation of biomaterials, smart delivery systems, and next-generation theranostics. In this article, we provide an updated review of the biological and structural characteristics of these alluring biomolecules, with a focus on those that have anticancer properties given that cancer is the leading cause of death worldwide. We also discuss supramolecular structuring and synthons based on the proline-based DKP privileged scaffold to serve as a model for the creation of compound libraries in search of ideal ligands, novel self-assembled nanomaterials, and bio-functional architectures.

Keywords: cyclic dipeptides; diketopiperazines; proline-based DKPs; drug discovery; privileged scaffold; supramolecular structuring

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Biomolecules

Writer Experience: 20+ Years

Plagiarism Report: Turnitin Plagiarism Report will be less than 10%

Restriction: Only one author may purchase a single paper. The paper will then indicate that it is out of stock.

What will I get after the purchase?

A turnitin plagiarism report of less than 10% in a pdf file and a full research paper in a word document.

In case you have any questions related to this research paper, please feel free to call/ WhatsApp on +919726999915