Description
Title: -Thalassemia Major Patients’ Biochemical Markers of Bone Turnover: A Single Center Study from Southern Pakistan
Abstract: Objectives. Even in children and adolescents receiving well-maintained transfusion and chelation therapy, skeletal complications in -homozygous thalassemic patients are rare but frequently disabling. The objective is to assess the hematological and biochemical markers of bone turnover in regularly transfused thalassemic patients and any potential correlations with demographic information. Methods. From March 2012 to March 2014, 36 people with -thalassemia major were enrolled in this prospective cross-sectional study. Complete blood counts, LFTs, serum ferritin, calcium, phosphorus, albumin, alkaline phosphatase, 25-OHvitamin D, and parathormone (PTH) levels were performed on all patients. Results. With a mean age of 12.56 5.9 years, there were 17 males and 19 females. While 25-OH vitamin D deficiency was present in 72.2% of thalassemic children and adolescents, hypocalcemia and hypophosphatemia were seen in 66.6% and 19.4% of those with the condition, respectively. 13.8% of patients had hypoparathyroidism, while 8.3% had hyperparathyroidism. Serum phosphorus and ferritin levels were directly correlated (P 0.05). There was no relationship between indirect bilirubin and calcium, parathyroid hormone, or skeletal parameters (P > 0.05). Conclusions. Patients with -thalassemia major have significantly altered biochemical profiles, and bone-related biochemical abnormalities like hypophosphatemia, 25-OHvitamin D deficiency, and hypocalcaemia are common in Pakistani patients with thalassemia major.
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Medicine
Sub Category: Hematology
Writer Experience: 20+ Years
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