Research Paper on Testing for antibiotic toxicity and susceptibility using microfluidics

Description

Title: Testing for antibiotic toxicity and susceptibility using microfluidics

Abstract: Few new antibiotics have been developed in the last 25 years, so the recent emergence of antimicrobial resistance has become a major concern for global policy makers. There is an urgent need for a low-cost, quick, and accurate set of tools and techniques that can aid in the discovery and development of new antimicrobial drugs in order to stop the death of millions of people around the world. Microfluidic platforms have become potential pharmacological study platforms in the last ten years. Recent studies have shown that microfluidic platforms can carry out quick tests for antibiotic susceptibility to determine the effectiveness of antimicrobial drugs. Additionally, the development of cell-on-a-chip and organ-on-a-chip platforms has made it possible to conduct early drug testing, giving more precise information about the pharmacokinetics and toxicity of drugs in conventional cell cultures at a quicker and less expensive stage of drug development, i.e., before testing on animals and people. In this review, we concentrate on the most recent advancements in microfluidic platforms for quick antibiotic susceptibility testing, bacterial persistence research, non-growing but metabolically active (NGMA) bacterial studies, antibiotic effectiveness on biofilms, antibiotic combinatorial effects, and in vitro antibiotic toxicity testing.

Keywords: microfluidic platforms; antibiotic susceptibility; biofilm; bacterial persistence; non-growing but metabolically active (NGMA) bacteria; combinatorial effect; antibiotic toxicity; cell-on-a-chip; organ-on-a-chip

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Bioengineering

Writer Experience: 20+ Years

Plagiarism Report: Turnitin Plagiarism Report will be less than 10%

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