Description
Title: Targeting Vascular and Other Pathologies by Inhibiting NADPH Oxidases: An Update on Recent Experimental and Clinical Studies
Abstract: In terms of health and disease, reactive oxygen species (ROS) can be advantageous or detrimental. Elevated levels of ROS cause a number of pathologies, including endothelial dysfunctions, colon cancer, and fibrosis, whereas low levels of ROS act as signaling molecules to control vascular tone and the growth and proliferation of endothelial cells. Numerous studies have been conducted on ROS and the cellular sources of these compounds as potential clinical intervention targets. Four NADPH oxidases (NOX1, NOX2, NOX4, and NOX5) play a significant role in homeostasis and disease, whereas different ROS sources are significant for various pathologies. NOX1 inhibition may be a promising therapeutic strategy because NOX1-generated ROS have been linked to hypertension. Due to their function in the production of extracellular and intracellular hydrogen peroxide, NOX2 and NOX4 oxidases are of particular interest (H2O2). The ROS-induced ROS release (RIRR) signaling is caused by hydrogen peroxide released by NOX4 activating NOX2, which in turn stimulates the release of mitochondrial ROS. NOX5’s increased ROS production causes atherosclerosis. In order to treat pathologies like diabetes, idiopathic pulmonary fibrosis (IPF), and primary biliary cholangitis, recent research on NOX enzymes and clinical trials inhibiting NADPH oxidases has been compiled in this review (PBC).
Keywords: ROS; NADPH oxidase; NOX
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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