Description
Title: Substituted 7-Methyl and 7-Formylindolizine Anti-Tubercular Activity and In Silico Study for Prospective Molecular Target Identification
Abstract: New series of indolizines with various substitutes were created, synthesized, and tested for their anti-mycobacterial activity in vitro against MDR and H37Rv strains of Mycobacterium tuberculosis (MTB). Numerous substances significantly inhibited the growth of MTB H37Rv strains. Additionally, it was discovered that indolizines 2d, 2e, and 4 were effective against MTB clinical isolates that had multiple resistance to rifampicin and isoniazid. The most effective anti-mycobacterial agent was found to be indolizine 4, which showed minimum inhibitory concentration (MIC) values of 4 and 32 g/mL against the H37Rv and MDR strains, respectively. The target enzymes CYP 121, malate synthase, and DNA GyrB ATPase all showed positive interactions in an in silico study for potential molecular target identification. All of the powerful molecules showed no toxicity against peripheral blood mononuclear (PBM) cell lines, indicating their potential for use in the treatment of drug-sensitive and drug-resistant tuberculosis.
Keywords: indolizines; Mycobacterium tuberculosis; multi-drug resistance; molecular modeling; multi-component reaction; whole-cell anti-TB screening
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Antibiotics
Writer Experience: 20+ Years
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