Description
Title: Structure and Function of Paraoxonase 3 in Coronary Artery Disease Pathophysiology
Abstract: Paraoxonases (PON1) have been studied for three decades and have the potential to mitigate the neurotoxicity of organophosphates that enter the bloodstream and prevent cholinergic crisis. The paraoxonase multigene family (PON1, PON2, and PON3) has recently been demonstrated to be crucial in the pathogenesis of cardiovascular disorders, such as coronary artery disease (CAD). On the long arm of human chromosome 7, the PON genes are grouped together (q21, 22). It has been established that they all function as antioxidants. PON3 is the least researched of them all because it is still unclear what exactly constitutes its physiological substrate. Our knowledge of its role in the pathogenesis of CAD has also been limited as a result, and potential therapeutic agents that could modulate its activity and expression in the blood and tissues have not yet been developed. In this review, we talk about the single nucleotide variations of the human PON3 enzyme and its structure and activity, which may help develop new clinical approaches to CAD prevention and treatment.
Keywords: Paraoxonase 3; polymorphisms; PON3 activity; statinase; coronary artery disease; HDL
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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