Description
Title: Spatiotemporal Control in Vascularized Tissues: Engineering
Abstract: The creation of a developed microvascular network that is functional and allows for adequate perfusion of oxygen and growth factors is a significant obstacle in the engineering of scalable three-dimensional tissues. Currently, soluble factors, instructive biomaterials, and vascular cells are used in biological methods to produce vascularized tissues. Combinations of physical and chemical signals, specifically the presentation of topographical growth factor signals, are being used to study angiogenesis and the subsequent development of a functional vascular bed within engineered tissues. Vascular networks can be created in massive and dense engineered tissues by spatiotemporal control of angiogenic signals. The developments are highlighted in this review. and investigations into the coordinated orchestration of angiogenic factors, differentiation of vascular cells, and microfabrication of intricate vascular networks as means of spatiotemporal control of these biological strategies. Topographical engineering methods, 3D bioprinting, and the incorporation or encapsulation of growth factors are fabrication strategies to achieve spatiotemporal control of vascularization. The vascularization of engineered tissues is highlighted in this article with a special emphasis on vascularized cardiac patches that are clinically scalable for myocardial repair. Finally, we talk about the current difficulties in successfully transferring engineered tissues and biomaterials into the clinical setting.
Keywords: vascularization; tissue engineering; 3d bioprinting; biomaterials; cardiac engineering;extracellular matrix
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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