Description
Title: Serpin Protease Inhibitors and Proteases in Cell Biology and Diabetes
Abstract: In order to maintain health, the balance between proteases and their inhibitors must be controlled. As a result, finding a way to target protease activity to encourage tissue regeneration and inhibit inflammation may present a fresh approach in the development of therapies for diabetes and other illnesses. Recent research has concentrated on serpins, which are serine protease inhibitors, as potential therapeutic targets. With the exception of Clade B, which mainly regulates intracellular proteases such as serine- and papain-like cysteine proteases, the protease inhibitors belonging to the serpin protein family are divided into 16 clades and are all extracellular. The most prominent, and occasionally conflicting, theories regarding how increasing or decreasing protease activity can improve pancreatic islet biology and inflammation are covered in this review. These potential discrepancies can be resolved at the molecular level because particular proteases and serpins regulate various signaling pathways and play similarly varied roles in the emergence of health and disease.
Keywords: diabetes; pancreatic islet; protease; serpin
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
Plagiarism Report: Turnitin Plagiarism Report will be less than 10%
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