Description
Title: Sensing and Metabolic Engineering of N-Acetylglucosamine to Reduce Human and Plant Pathogens
Abstract: Pathogens that affect both humans and plants have evolved to use a variety of carbon sources. The amino sugar N-acetylglucosamine (GlcNAc) is one of the main carbon sources used by a number of human and phytopathogens. GlcNAc controls the expression of numerous virulence genes. pathogens’ genes. In actuality, the regulation of virulence and pathogenesis in a number of human pathogens, such as Candida albicans, Vibrio cholerae, Leishmania donovani, Mycobacterium, and phytopathogens like Magnaporthe oryzae, depends on GlcNAc catabolism. Additionally, GlcNAc is a well-known structural element of the cell walls of numerous bacterial and fungal pathogens, indicating a potential role in cell signaling. Numerous studies have been conducted in the recent years. to investigate GlcNAc sensing, signaling, and metabolism to better comprehend the pathophysiological roles of GlcNAc and to find new drug targets. We present recent findings on GlcNAc-mediated cell signaling and pathogenesis in this review. We also describe the GlcNAc metabolic process works. In order to reduce the pathogens’ virulence and control the spread of disease and crop productivity, a specific pathway can be targeted.
Keywords: N-Acetylglucosamine; pathogens; virulence; colonization; NAG1; DAC1; HXK1; NGT1; chitin; plant immunity
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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