Description
Title: Review of Recent Advances in Nano-Based Theranostic Platforms for Breast Cancer
Abstract: Breast cancer (BC) has a wide range of histological and molecular subtypes and is a highly metastatic multifactorial disease. The mortality rate in British Columbia has decreased over the past 50 years as a result of recent advancements. The use of nanomedicine in clinical settings has made the detection and treatment of many cancers possible. Doxil® and Abraxane®, two nanomedicine products, have already been widely used for adjuvant therapy for BC with positive clinical results. However, these products were not initially intended for the treatment of BC; rather, they were developed for general anticancer purposes. In recent years, a number of innovative and fruitful nanotherapeutic approaches and devices have been created in response to a better understanding of the molecular biology of BC. Multifunctionalized nanostructures are emerging as potential delivery systems for improved chemotherapy in BC patients in this context. A wide variety of materials, including proteins, lipids, polymers, and hybrid materials, can be used to design these nanostructures and can be tailored for particular uses against BC. A promising approach to treating triple-negative BC is selective targeting of BC cells, which activates programmed cell death in BC cells. As of right now, traditional BC screening techniques like mammography, digital breast tomosynthesis (DBT), ultrasonography, and magnetic resonance imaging (MRI) are either expensive or subject the user to harmful radiation. Therefore, it is necessary to develop analytical methods for detecting BC that are long-lasting, biocompatible, reproducible, highly sensitive and selective, with a very low detection limit. Nanostructures are used alone or in combination with many molecules to detect BC biomarkers. The goal of this review is to highlight recent developments in nanomedicine for the treatment and diagnosis of BC, with a focus on the identification of BC cells that overexpress epidermal growth factor receptors. In order to further improve cancer specificity, antitumorigenic effects, anti-metastasis effects, and drug resistance reversal effects, researchers may use the knowledge gained from these strategies to design and develop more tailored nanomedicine for BC.
Keywords: breast cancer; cancer imaging; theranostics; nanoparticles; nanotechnology
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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