Research paper on Relationship between Higher Plasma Atherogenic Index and Oxidative Stress in a Group of Sickle Cell Anemia Patients in Cameroon

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Title: Relationship between Higher Plasma Atherogenic Index and Oxidative Stress in a Group of Sickle Cell Anemia Patients in Cameroon

Abstract: Dyslipidemia is a serious risk factor for cardiovascular diseases brought on by oxidative stress in Africa and is extremely common in sickle cell anemia (SCA) patients. The purpose of this study was to look into the relationship between oxidative stress and higher atherogenic index of plasma (API) in a group of SCA patients in Cameroon. Methods. Between May and October 2017, 85 homozygote SS patients (both sexes) were enrolled at the Central hospital of Yaounde in Cameroon. After obtaining signed informed consent, plasma was collected to determine the lipid profile and RBC lysate solution was used to investigate some oxidative stress markers using spectrophotometric techniques. Results. The 85 patients who were a part of our study had an average age of 30 5 years, with a female to male ratio of 0.97. 22.4% of the patients showed a higher level of plasma atherogenic index, and the majority of the patients (52–81%) had dyslipidaemia. +e patients had malondialdeheyde (MDA) concentrations that were at least 1,334 times higher than those of normal-level patients when their total cholesterol (TC) and low-density lipoprotein (LDL-C) levels were higher (>240 mg/dl and >159 mg/dl, respectively). The higher atherogenic plasmatic index (API) increased significantly (p 0.05) with the concentration of MDA in the same patients. Except for HDL-C, the other lipid profile variables were significantly correlated with total antioxidant capacity and reduced glutathione (GsH) (p 0.05). (TAC). There was a linear relationship between the elevated MDA and higher API that was significant (p 0.05). Conclusion. Dyslipidemia causes higher API and more oxidative stress, which in patients with SCA results in coronary vascular disease.

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Medicine

Sub Category: Hematology

Writer Experience: 20+ Years

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