Description
Title: Regenerative medicine uses for ultrasound-mediated gene delivery
Abstract: As the current use of viral vectors can present with significant limitations, research on the ability of non-viral gene delivery systems to induce tissue regeneration is ongoing. Despite Non-viral delivery techniques have been improved to match the efficiency of their viral counterparts after initially demonstrating lower gene transfection and gene expression rates. Sonoporation, also known as ultrasound-mediated gene transfer, has been found to significantly increase DNA uptake and expression in cells throughout many organ systems. It works by temporarily permeabilizing the membrane. In comparison to other non-viral delivery techniques, it also provides a safer profile. In both ectopic and disease models, studies have shown that microbubble-enhanced sonoporation can significantly stimulate tissue regeneration, including vascular and bone tissue. Although sonoporation is currently being used in clinical trials for other indications, there have been no studies on its use for tissue regeneration in spite of this, suggesting that the technique is safe for use in a clinical setting. We outline the pre-clinical research on sonoporation’s application to tissue regeneration that has been done up to this point in this review. Additionally, the methods employed to lengthen the efficiency and duration of sonoporation-induced gene transfer are examined, as well as potential roadblocks to clinical translation.
Keywords: gene therapy; microbubbles; regenerative medicine; sonoporation; tissue regeneration; ultrasound-targeted microbubble destruction (UTMD)
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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