Description
Title: Real-World Evaluation of Clinical Results in Lower-Risk Myelofibrosis Patients Receiving Ruxolitinib
Abstract: There have been few trial-based evaluations of ruxolitinib in patients with lower-risk myelofibrosis (MF), and no studies have evaluated the drug in a real-world population. We used a retrospective, observational review of anonymized US medical record data of patients with IPSS low-risk (n = 25) or intermediate-1-risk (n = 83) MF to assess changes in spleen size and constitutional symptoms during ruxolitinib treatment. Male patients made up the majority (low risk, 60%; intermediate-1 risk, 69%). At the time of medical record abstraction, the majority of patients (92% and 77%) were still receiving ruxolitinib (median observation/exposure time, 8 months). From diagnosis (56%) to best response (12%), the percentage of patients with moderate or severe palpable splenomegaly (10 cm) decreased. The most prevalent constitutional symptom, fatigue, was reported by 47% of patients. Changes in the distribution of severity from more to less severe from diagnosis to best response were seen for the majority of symptoms in both risk groups. In actual clinical settings, ruxolitinib treatment resulted in a significant reduction in spleen size in both patients with low-risk and intermediate-1-riskMF. The distribution of severity for the majority of the symptoms was clearly improved while taking ruxolitinib. These results imply that ruxolitinib therapy may be clinically beneficial for patients with lower-risk MF.
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Medicine
Sub Category: Hematology
Writer Experience: 20+ Years
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