Description
Title: RAS Nanocluster Lipid Profiles Control RAS Function
Abstract: Human cancers frequently contain the lipid-anchored RAS (Rat sarcoma) small GTPases (guanosine triphosphate hydrolases). Targeting the enzymatic activities of RAS using conventional methods has proven to be challenging. On the other hand, RAS pathology and function are mostly confined to nanoclusters on the plasma membrane (PM). Lipids play a crucial structural role in these PM signaling platforms. However, it is still unclear how RAS nanoclusters selectively enrich different lipids in the PM, how various lipids affect RAS signaling and oncogenesis, and whether RAS nanoclusters’ selective lipid sorting can be targeted. Recent developments in molecular dynamic simulations and quantitative super-resolution imaging have allowed for a thorough characterization of RAS/lipid interactions. In this review, we discuss the most recent research on the selective lipid composition (with headgroup and acyl chain specificities) within RAS nanoclusters, the precise mechanisms for the selective lipid sorting of RAS nanoclusters on the PM, and the effects on RAS function and pathology of perturbing lipid compositions within RAS nanoclusters. We also go over various methods for modifying the lipid composition of RAS nanoclusters on the PM.
Keywords: RAS; nanoclusters; plasma membrane; phospholipids; phosphatidylserine; lipid acyl chain
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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