Description
Title: Progress and Challenges in Microneedle-Based Natural Polysaccharide for Drug Delivery Systems (DDS)
Abstract: In this focused progress review, topical creams, patches, and hypodermic needles are the most commonly used forms of transdermal drug delivery. The skin barrier is bypassed by low-invasive 3D biomedical devices called microneedles (MNs) (or microneedle arrays), which have both systemic and localized pharmacological effects. Because of their physicochemical characteristics, biomaterials like carbohydrates have previously been widely used to create microneedles (MNs). Carbohydrates allow for the design and development of tunable properties and functionalities due to their diverse range of functional groups. Numerous microneedle products have entered the market in recent years, but much research must still be done to address the various issues before microneedles can be successfully sold. So, there is a great chance that carbohydrate-based microarrays will advance sensing, drug delivery, and biologics restitution. A thorough discussion of carbohydrates, including hyaluronic acid, chitin, chitosan, chondroitin sulfate, cellulose, and starch, is presented in this review. It also discusses the various drug delivery techniques, mechanical characteristics, and clinical translation of biomaterial-based MNs, as well as the marketing opportunities for their commercialization. The article concludes by summarizing the prospects for carbohydrate-based MNs, which are the newest category of topical drug delivery systems.
Keywords: microneedles; sustained and controlled release; transdermal drug delivery; natural polysaccharide
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biology
Writer Experience: 20+ Years
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