Description
Title: Phytochemicals as Synucleinopathies-Related Gene Regulators
Abstract: A group of neurodegenerative diseases known as synucleinopathies are characterized by the buildup of -synuclein aggregates in neurons, nerve fibers, or glial cells. The synucleinopathies include Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy. These three conditions make up the majority of synucleinopathies. They all grow as a result of the interaction between genetic and environmental factors. Recent research indicates that epigenetic mechanisms are crucial to the emergence of synucleinopathies. There is growing interest in plant-derived chemicals as a potential treatment option for these disorders because there is currently no disease-modifying therapy for them. Phytochemicals are substances with biological activity that have a connection to plants and may have an impact on human health. Due to their antioxidant, anti-inflammatory, and anti-apoptotic qualities as well as their capacity to lessen cellular stress, phytochemicals with neuroprotective activity target various components in pathogenic pathways. Recent studies have shown that phytochemicals’ beneficial effects may be attributed to their capacity to regulate the expression of genes linked to synucleinopathies and other diseases. These substances can act as epigenetic regulators by influencing histone modification, DNA methylation, and RNA-based mechanisms, or they can control transcription directly via transcription factors (TFs). Here, we provide a summary of recent findings regarding how phytochemicals affect synucleinopathies’ pathogenesis by regulating gene expression.
Keywords: synucleinopathies; Parkinson’s disease; α-synuclein; epigenetics; neurodegeneration; protein aggregation; dementia with Lewy bodies; multiple system atrophy; DNA methylation; histone modifications; phytochemicals; dietary supplements
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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