Research Paper on Patients with sickle cell disease in Egypt and vitamin D-related nonskeletal complications

Description

Title: Patients with sickle cell disease in Egypt and vitamin D-related nonskeletal complications

Abstract: Many sickle cell disease (SCD) patients have lower levels of vitamin D, but research on the relationship between vitamin D deficiency (VDD) and the occurrence or severity of different SCD complications is still preliminary. Our research sought to identify the prevalence of vitamin D deficiency among SCD patients in Egypt and link it to the disease’s clinical progression. Using an enzyme-linked immunosorbent assay, we measured the levels of 25-hydroxy vitamin D in 140 children (aged 4.3 to 15.5 years), 80 patients with SCD, and 60 controls. Compared to 26.7% of controls, 60% of SCD had vitamin D deficiencies. Significantly more SCD patients than controls had severe VDD. Two groups of patients were created: the Normal group (32 patients) and the Deficient group (48 patients). Regarding age, height percentile, the presence of clinical jaundice, and osseous changes, there were statistically significant differences between the 2 groups (P values 0.043, 0.024, 0.001, and 0.015, respectively). While the levels of aspartate aminotransferase, lactate dehydrogenase, total and indirect bilirubin, and hemoglobin were significantly lower in the Deficient group (P values 0.022 and 0.004, respectively), these values were significantly higher in the same group (P values 0.006, 0.001, 0.038, and 0.016, respectively). In the Deficient group, there was a significantly higher frequency of blood transfusions, hospitalizations, vasoocclusive crises, history of bone fractures, and recurrent infections. These results imply that VDD might contribute to the pathogenesis of hemolysis and other SCD complications. Patients with SCD should receive vitamin D monitoring and supplementation as standard medical care to possibly improve their health outcomes.

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Medicine

Sub Category: Hematology

Writer Experience: 20+ Years

Plagiarism Report: Turnitin Plagiarism Report will be less than 10%

Restriction: Only one author may purchase a single paper. The paper will then indicate that it is out of stock.

What will I get after the purchase?

A turnitin plagiarism report of less than 10% in a pdf file and a full research paper in a word document.

In case you have any questions related to this research paper, please feel free to call/ WhatsApp on +919726999915