REsearch Paper on Patients with chronic leg ulcers and sickle cell anemia have increased hypercoagulability.

Description

Title: Patients with chronic leg ulcers and sickle cell anemia have increased hypercoagulability.

Abstract: A hypercoagulable condition known as sickle cell anemia (SCA) is linked to a propensity for venous thromboembolism. More SCA patients are surviving into adulthood thanks to improvements in healthcare quality, which is correlated with an increase in end-organ damage and chronic complications like chronic leg ulcers (CLUs). The purpose of this study was to investigate whether coagulation is affected in SCA patients with CLU. These ulcers rarely develop during the first ten years of life and are painful, slow to heal, recurrent, and painful. Selected coagulation tests were used to evaluate 145 participants (50 SCA with CLU, 50 SCA without CLU, and 45 with haemoglobin AA) to determine their coagulation profiles. The CLU group’s mean hemoglobin (Hb) concentration was the lowest in the SCA. Comparing SCA patients to HbAA patients, SCA patients had higher mean platelet counts, shorter mean aPTTs, and slightly longer mean PTs. Patients with SCA who were also taking CLUs had a significantly shorter aPTT (p 0.035) and HbAA (p 0.009). The mean PT showed a significant difference between SCA with CLUs patients and HbAA (p 0.017), as well as between SCA without CLU and HbAA (p 0.014). The mean D-dimer levels in SCA patients with and without CLUs were higher than those in HbAA. Hb concentration and CLU duration had a negative correlation (r – 0.331, p 0.021). In summary, our study shows that SCA patients with CLUs have increased hypercoagulability. It is unclear what, if any, role the increased hypercoagulability plays in the pathogenesis of CLUs in SCA because we did not test for platelet activation. Finding out whether antiplatelet medications or/and anticoagulants hasten CLU healing in SCA patients will be useful.

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Medicine

Sub Category: Hematology

Writer Experience: 20+ Years

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