Research Paper on Patients admitted to the obstetrics and gynecology departments of two tertiary care hospitals in Central India who have infectious and non-infectious conditions are prescribed antibiotics

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Title: Patients admitted to the obstetrics and gynecology departments of two tertiary care hospitals in Central India who have infectious and non-infectious conditions are prescribed antibiotics

Abstract:  Patients who are admitted to obstetrics and gynecology (OBGY) departments are at an increased risk of infections and subsequent antibiotic prescription, which may increase antibiotic resistance (ABR). Antibiotic surveillance, one of the main strategies against ABR, is infrequently carried out in low- and middle-income nations. The purpose of this study was to describe and evaluate the patterns of antibiotic prescription among inpatients in the OBGY departments of two tertiary care hospitals in Central India: one teaching (TH) and one nonteaching (NTH). Methods: For three years, prospective data on patient demographics, diagnoses, and prescribed antibiotics were gathered. Patients were split into three groups: surgical, nonsurgical, and possible surgical indications. Patients were first divided into two categories: infectious and non-infectious diagnosis. The Defined Daily Doses (DDDs) were calculated per 1000 patients, the International Classification of Disease system version-10, and the Anatomical Therapeutic Chemical classification system were used to code the data. Results: There were 5558 total patients included in the study; 81% of the TH patients and 85% of the NTH patients received antibiotics (p 0.001). The nonsurgical group’s inpatients frequently received antibiotic prescriptions despite having no known bacterial infections (TH-71%; NTH-75%). Broad-spectrum, fixed-dose combinations (FDCs) of antibiotics were prescribed more frequently in the NTH than the TH in both categories. In both categories, the TH was prescribed with higher DDD/1000 patients overall. Conclusions: Patients who had no known infectious indications were frequently prescribed antibiotics. Antibiotic overprescribing and unwarranted antibiotic prescriptions indicate the threat of ABR and call for immediate action. Another issue that needs attention is the prescription of antibiotics to inpatients with symptoms of nonbacterial infection. Measures to improve antibiotic prescribing practice include looking into the underlying causes of prescribing antibiotics for undiagnosed conditions and creating and implementing antibiotic stewardship programs.

Keywords: antibiotics; obstetrics and gynaecology; inpatients; surgical prophylaxis; bacterial infections; fixed dose combinations of antibiotics; Central India

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Antibiotics

Writer Experience: 20+ Years

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