Description
Title: Ophthalmic Optogenetics Advances: Methods and Applications
Abstract: Optogenetic developments in recent years show promise for restoring vision in degenerative eye diseases. Optogenetic methods use light to regulate the cellular activity of desired cells. Even though optogenetics is a relatively new field of research, a variety of therapeutic options are already being investigated in pre-clinical and phase I/II clinical trials with the goal of creating novel, secure, and efficient treatments for serious eye conditions that can result in blindness, like retinitis pigmentosa and glaucoma. By introducing light-sensitive proteins into downstream retinal neurons that lack intrinsic light sensitivity, optogenetic approaches to visual restoration primarily aim to replace missing or damaged photoreceptors. Such strategies are appealing because they are unconcerned with the genetic underpinnings of retinal degeneration, which gives rise to the possibility that all types of retinal dystrophic and degenerative diseases may one day be curable. By acting as crucial tools for determining clinically applicable therapeutic targets and for analyzing the pathogenesis of retinal degeneration, optogenetic strategies can also have a significant impact on translational research. For instance, the CRY-CIBN optogenetic system has recently been used to study animal glaucoma models, which may point to OCRL’s potential involvement in the control of intraocular pressure in trabecular meshwork. It seems essential to take into account the opportunities and challenges that these therapies may present as optogenetic strategies are currently the subject of intense research. Here, we examine the most recent and promising optogenetic molecules, vectors, and treatments for glaucoma and retinal degeneration. We also provide an overview of the early findings from ongoing clinical studies for vision restoration.
Keywords:retinitis pigmentosa; optogenetics; glaucoma; degenerative eye diseases
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
Plagiarism Report: Turnitin Plagiarism Report will be less than 10%
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