Description
Title: Novel Tools for Modeling Human Cardiac Biology and Disease: Heart Organoids and Engineered Heart Tissues
Abstract: Organoids are three-dimensional in vitro cell constructs that, to a large extent, recapitulate organ characteristics and structure. They serve as particularly helpful models for the study of inaccessible human states like embryonic and fetal development or the early stages of disease in adults. Organoids have been used to model a variety of different organs and disease states in recent years. However, compared to other organoid types, the technology for their creation and use in cardiovascular studies has lagged significantly (e.g., brain, pancreas, kidney, intestine). This is surprising considering that congenital heart disease (CHD) and cardiovascular disease (CVD) together account for one of the most unmet medical needs in the contemporary world and are, respectively, the most common birth defects in humans and the leading cause of mortality and morbidity in the developed world. Establishing in vitro models of the human heart that accurately recapitulate its biology and function is imperative in order to facilitate basic and translational studies for the creation of novel therapeutics. Due to the complexity of the heart, it has proven challenging to produce heart organoids that truly resemble the heart; however, significant progress has been made recently to overcome this challenge. The development of novel heart organoid generation techniques, their benefits and drawbacks, and their translational applications for advancing cardiovascular research and the treatment of heart conditions will all be covered in this review.
Keywords: heart; organoid; pluripotent stem cell; cardiovascular; stem cell; development; cardiovascular disease; self-organization; directed assembly
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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