Description
Title: Novel Therapeutics with Anti-Inflammatory and Anti-Cancer Potential: Oximes
Abstract: Because of their significant functions as acetylcholinesterase reactivators, oximes have been studied for decades. Numerous oximes with beneficial pharmaceutical properties have been discovered over the past 20 years, including substances with antibacterial, anticancer, anti-arthritis, and anti-stroke activities. Over 40 different kinases, including AMP-activated protein kinase (AMPK), phosphatidylinositol 3-kinase (PI3K), cyclin dependent kinase (CDK), serine/threonine kinases glycogen synthase 3 / (GSK-3 /), Aurora A, B-Raf, Chk1, death-associated protein-kinase-related 2 Proteinase 3, human neutrophil elastase, and lipoxygenase 5 are all inhibited by specific oximes. Unlike carbonyl groups, which only have one H-bond acceptor, oxime groups have two H-bond acceptors (nitrogen and oxygen atoms) and one H-bond donor (OH group). Despite slight variations in the compound’s overall size and shape, this characteristic, coupled with the high polarity of oxime groups, may result in a noticeably different mode of interaction with receptor binding sites than corresponding carbonyl compounds. Nitric oxide can also be produced by oximes. The oximes, kinase inhibitors with anticancer and anti-inflammatory properties, are the main topic of this review. Also discussed are oximes with non-kinase targets or anti-inflammatory activity mechanisms.
Keywords: oxime; kinase inhibitor; indirubin; nitric oxide; molecular modeling; inflammation; cancer
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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