Research Paper on Neuroblastoma’s genetic and histopathological heterogeneity and targeted therapeutic strategies for subgroups of extremely unfavorable histology

Description

Title: Neuroblastoma’s genetic and histopathological heterogeneity and targeted therapeutic strategies for subgroups of extremely unfavorable histology

Abstract: The clinical behaviors of peripheral neuroblastic tumors (neuroblastoma, ganglioneuroblastoma, and ganglioneuroma) (spontaneous regression, tumor maturation, and aggressive progression) are diverse and wide, and they are closely correlated with the genetic and molecular characteristics of the individual tumors. The International Neuroblastoma Pathology Classification, a biologically relevant and prognostically significant morphology classification that separates the disease’s favorable histology (FH) and unfavorable histology (UH) groups, forecasts the likelihood that patients with the highest hazard ratios will survive. The UH group’s tumors are also heterogeneous, as shown by the most recent advancements in neuroblastoma research using precision medicine techniques, which have led to the identification of four distinct subgroups: MYC, TERT, ALT, and null. Due to their extremely aggressive clinical behavior, the first three subgroups of them are collectively referred to as extremely unfavorable histology (EUH) tumors. These EUH tumors are distinguished from one another, as suggested by their names, by the potential targets that can be identified molecularly and immunohistochemically, such as overexpression of MYC-family proteins, overexpression of TERT, and loss of ATRX (or DAXX). The latter portion of this paper discusses the current state of therapeutic targeting of these EUH tumors for the eventual creation of efficient patient treatments.

Keywords: neuroblastoma; International Neuroblastoma Pathology Classification; extremely unfa-
vorable histology; MYC; TERT; ALT

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Biomolecules

Writer Experience: 20+ Years

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