Description
Title: Modern Therapeutic Insights from Pediatric High-Grade Glioma and Diffuse Intrinsic Pontine Glioma Molecular Biology (DIPG)
Abstract: Among the most difficult childhood cancers to treat are diffuse intrinsic pontine glioma (DIPG), which has a 5-year survival rate of only 2%, and pediatric high-grade gliomas (pHGG) and brainstem gliomas. While radiation alone is the recommended course of treatment for DIPG, surgery, radiation, and chemotherapy continue to be the gold standard of care for pHGG as a whole. Unfortunately, these treatments have little to no reliable biomarkers of efficacy and are not specific for malignant glioma cells. Recent research has shown that the aggressiveness of these cancers is influenced by epigenetic disruption caused by highly conserved mutations in DNA-packaging histone proteins in pHGG, particularly DIPG. In this review, we address unexplored mechanisms in pre-clinical models and clinical trial data from pHGG patients while posing open questions. Therapeutics that target chromatin modifiers and other epigenetic weaknesses that can be used in pHGG therapy will receive special attention. The development of safe and effective treatments for pHGG patients may be influenced by further clarification of rational therapeutic combinations.
Keywords: pediatric; high-grade glioma; DIPG; therapeutics; epigenetics; clinical trial
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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