Description
Title: Methicillin-Resistant Staphylococcus aureus Prevalence and Characterization from Community- and Hospital-Related Infections: A Tertiary Care Center Study
Abstract: Both in the community and in hospitals, the methicillin-resistant Staphylococcus aureus (CA-MRSA) has become more commonplace. In a tertiary care hospital in Mangalore, India, the purpose of this study was to identify the prevalence, molecular characteristics, and profiles of antibiotic resistance of CA-MRSA from community- and hospital-associated infections. Out of 520 S. aureus isolates, 158 were obtained from outpatients (OP) and 362 from inpatients (IP) (OP). A further analysis was done on 172 MRSA isolates that were obtained from 94 inpatients and 38 outpatients and had complete clinical information. 51 (38.6%) of them were HA-MRSA (IP-52.1%, OP-5.3%) and 81 (61.4%) of them were CA-MRSA (IP-47.9%, OP-94.7%). All (100%) MRSA isolates tested positive for the mecA gene. SCCmec typing revealed that SCCmec type IV (50.6%) and SCCmec type V (66.7%) were present in CA-MRSA isolates, whereas HA-MRSA isolates contained SCCmec type I (41.2%), SCCmec type III (19.6%), SCCmec type IV (31.4%), and SCCmec type V (25.5%). A gene known as Panton-Valentine Leukocidin (PVL) was discovered in 7.8% of true HA-MRSA, 43.1% of HA-MRSA with SCCmec types IV and V, and 70.4% of CA-MRSA. The disc diffusion method was used to determine the profiles of antibiotic resistance. To identify MRSA, cefoxitin resistance was used. Regarding resistance to cephalexin, cefotaxime, levofloxacin, linezolid, and teicoplanin, a significant difference (p 0.05) was found between CA-MRSA and HA-MRSA. In contrast to HA-MRSA, which exhibited resistance to ciprofloxacin (80.4%), erythromycin (80.1%), cefotaxime (70.6%), ofloxacin (58.8%), clindamycin (47.1%), and levofloxacin (41.2%), CA-MRSA was primarily resistant to ciprofloxacin (86.4%), erythromycin (66.7%), ofloxacin (49.4%), This study details the prevalence of CA-MRSA in healthcare facilities and the community, as well as the potential switchover of HA-MRSA to CA-MRSA. The findings from our study highlight the requirement for quick action to handle this developing crisis in healthcare settings.
Keywords: CA-MRSA; PVL; SCCmec typing; multi-drug resistance; HA-MRSA
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Antibiotics
Writer Experience: 20+ Years
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