Research Paper on Mentha piperita L. and Rosmarinus officinalis L. Essential Oils’ Chemical and Antimicrobial Characterization and In Vitro Potential Cytotoxic Effect on Human Colorectal Carcinoma Cells

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Title: Mentha piperita L. and Rosmarinus officinalis L. Essential Oils’ Chemical and Antimicrobial Characterization and In Vitro Potential Cytotoxic Effect on Human Colorectal Carcinoma Cells

Abstract: One of the cancer types that is most frequently diagnosed is colorectal cancer, and the treatment options are frequently aggressive and call for advancements. The secondary metabolites of aromatic plants known as essential oils (EOs) have potent pharmacological properties and have been shown to be effective against a variety of pathologies, including cancer. The biological effects of Mentha piperita L. (M EO) and Rosmarinus officinalis L. (R EO) essential oils (antimicrobial, antioxidant, antiinflammatory, and cytotoxic in various cancer cells) are well known, but their potential as adjunctive treatments for colorectal cancer is understudied. A colorectal cancer cell line called HCT 116 was used in this study to examine the M EO and R EO in terms of their chemical make-up, antioxidant, antimicrobial, and cytotoxic effects. Menthone, menthol, eucalyptol, -pinene, and L-camphor were identified as the major compounds in M EO and R EO, respectively, according to the gas chromatographic analysis. In HCT 116 cells, M EO showed strong antimicrobial activity, tempered antioxidant activity, and a minimal cytotoxic effect. R EO demonstrated a high level of cytotoxicity against colorectal cancer cells and a negligible antimicrobial effect. The cytotoxic impact of both essential oils on the non-cancerous cell line HaCaT was negligible. These findings could serve as an experimental foundation for future study on the potential anticancer applications of M EO and R EO.

Keywords: Mentha piperita L. essential oil; Rosmarinus officinalis L. essential oil; colorectal cancer; cytotoxicity; antimicrobial potential

Paper Quality: SCOPUS / Web of Science Level Research Paper

Subject: Chemistry

Writer Experience: 20+ Years

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