Description
Title: LIVER Tissue Engineering Advances Based on 3D Hepatic Organoids
Abstract: The rapid de-differentiation in 2D culture conditions that limited the usability of functional Primary human hepatocytes (PHH) had been a barrier to liver-associated diseases and tissue engineering approaches. It has been demonstrated that 3D-growing cells can more accurately mimic the in vivo microenvironment, which will aid in keeping the in vitro cultures’ metabolic activity, phenotypic characteristics, and longevity. Again, it is acknowledged that the method of culture and the type of cell population are crucial factors in the functional maintenance of primary hepatocytes. Hepatic organoids, which are microtissues created by the self-assembly of hepatic cells, were able to maintain hepato-specific characteristics over an extended period of time in vitro. Hepatic organoids were subsequently acknowledged as a useful tool for evaluating potential treatments and accurately simulating liver diseases. The purpose of this review is to highlight the significance of 3D hepatic organoid culture. over other customary 2D and 3D culture models, as well as its suitability for liver tissue engineering.
Keywords: liver tissue engineering; hepatic organoids; hepatic function; hepatocytes; 3D culture
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Bioengineering
Writer Experience: 20+ Years
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