Description
Title: Innate Immunity: The Function of Intestinal Alkaline Phosphatase
Abstract: Developed to primarily protect the gut, intestinal alkaline phosphatase (IAP) is a multifunctional protein. The observation that IAP expression is deficient in many gastrointestinal-related disorders, such as inflammatory bowel disease, necrotizing enterocolitis, and metabolic syndrome, and that exogenous IAP supplementation improves the outcomes connected with these disorders undersells the role of IAP in maintaining intestinal homeostasis. Studies using transgenic IAP-knock out (IAP-KO) mouse models also bolster the significance of IAP’s protective function in the intestine. The downstream mechanisms of this protein in mammalian cell lines have also been examined in vitro using exogenous IAP supplementation and cellular overexpression of IAP. Detoxification of lipopolysaccharide (LPS), maintenance of gut barrier integrity, control of gut microbial communities, and anti-inflammatory activities are a few of the innate immune functions of IAP. The induction of autophagy is a recently discovered novel function of IAP. IAP has been used in phase 2a clinical trials to treat conditions like sepsis-associated acute kidney injury because of its crucial role in gut physiology and excellent safety profile. Here, we expand on the many excellent reviews that discuss the function of IAP in physiology and pathophysiology by discussing its role in innate immunity by examining its effects on bacteria as well as host cells. We’ll also talk about the connection between IAP and autophagy and how these two pathways might work together to safeguard the gut.
Keywords: intestinal alkaline phosphatase; LPS; autophagy; barrier function; inflammation; gut microbes
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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