Description
Title: Inbred BXD Recombinant Mice as a Model for Researching Neurotoxicity
Abstract: BXD recombinant inbred (RI) lines are a genetic reference population derived from a cross between C57BL/6J (B6) and DBA/2J (D2) mice. These lines have recombinant chromosomes with B6 or D2 haplotype segments due to meiotic recombination events. The quantitative trait loci (QTLs), which are the sites of segregating genetic polymorphisms, are crucial for comprehending the genetic diversity affecting the severity and susceptibility of human disease. The typical method for locating naturally occurring polymorphisms that affect intricate phenotypes is QTL mapping. In this process, phenotypic values assessed in a segregating population are associated with genotypic values at markers of known genomic locations. In fact, BXD RI strains offer an effective tool for researching neurotoxicity brought on by various substances. We discuss the use of BXD RI lines in this review to comprehend the underlying mechanisms of neurotoxicity in response to exposure to ethanol, cocaine, metals, and pesticides.
Keywords: genetic; alcohol; metals; cocaine; pesticides
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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