Description
Title: Immune Response and Vaccination Strategies in Leishmaniasis: Host-Pathogen Interaction
Abstract: The trypanosomatid family member genus Leishmania, which is a zoonotic and vector-borne infectious disease, is the cause of leishmaniasis. An insect vector and a mammalian host are both necessary components of the protozoan parasite’s digenetic life cycle. Leishmaniasis is a neglected tropical disease with over 90 endemic countries, 1 million new cases, and 20,000 fatalities each year. It is a major global public health issue. Species-specific pathologic disorders, ranging in severity from self-healing cutaneous lesions to disseminating muco-cutaneous and lethal visceral manifestations, can develop as a result of leishmania infection. Leishmaniasis severity and prognosis are influenced by the antigenic epitope properties of the parasite, the physiology of the vector, and most importantly, the immune response and immune status of the host. Innate and adaptive immune responses are examined, along with various approaches to vaccine development, in this review of the leishmaniasis host-pathogen interaction.
Keywords: Leishmania; sand fly; macrophage; innate immunity; Th1/Th2; vaccine
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biology
Writer Experience: 20+ Years
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