Description
Title: Immune Checkpoint Inhibitors Are Increasingly Used to Treat Myelodysplastic Syndromes
Abstract: Acute myeloid leukemia and indolent, asymptomatic cytopenias are just a few of the manifestations of the heterogeneous group of diseases known as myelodysplastic syndromes (MDS), which also have ineffective hematopoiesis as one of their main symptoms (AML). Clonal cells and their surrounding microenvironments exhibit genetic and epigenetic abnormalities, which lead to MDS. MDS and other autoimmune diseases have been linked in studies. Multiple immune mechanisms have been found in MDS, indicating that immune dysregulation may be at least partially responsible for the pathogenesis of the disease. As a result, thorough research has been done on the use of immunomodulatory drugs as potential therapeutics. While immune check point inhibition is well known as a treatment option for advanced solid tumors, it is a novel strategy being investigated in hematologic cancers, including high risk MDS. The effectiveness of these medications in MDS, both as frontline therapy and in relapse, as well as in combination with other medications, is being studied in a number of trials. In this review, we look at recent studies examining the effectiveness of immune checkpoint inhibitors in MDS.
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Medicine
Sub Category: Hematology
Writer Experience: 20+ Years
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