Description
Title: Immune Cell Response to Ca2+-Independent Phospholipase A2 (iPLA2)
Abstract: A member of the PLA2 family, Ca2+-independent phospholipase A2 (iPLA2) is thought to play a variety of biological roles, including membrane remodeling, cell proliferation, bone formation, male fertility, cell death, and signaling. Due to this involvement, iPLA2 activation has been linked to a number of diseases, including diabetes, cancer, glaucoma, periodontitis, neurological disorders, and other metabolic disorders. The role that iPLA2 plays in triggering inflammation has attracted more attention recently. We review this topic in the context of an iPLA2 link with macrophages and T-cells in light of the potential role of iPLA2 in the emergence of autoimmune diseases.
Keywords: iPLA2β; macrophages; T-cells; inflammation; eicosanoids; resolvins
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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