Description
Title: Hybrid Epithelial-to-Mesenchymal Transition: Emerging Concepts in Cancer development
Abstract: In the complicated process known as epithelial mesenchymal transition (EMT), epithelial (E) cells lose their adherens junctions, change into mesenchymal (M) cells, and acquire motility. distant organ metastasis A spectrum of E/M transition states, best referred to as hybrid/partial/intermediate EMT, has replaced the binary phase of interconversion of pure E to M cells and vice versa in the modern understanding of EMT. As a plastic transient state, hybrid EMT is home to cells that co-express E and M markers and have high tumorigenic potential, which can result in stemness, metastasis, and therapy resistance. Numerous preclinical and clinical studies offered proof that the E/M phenotypes coexisted. The hybrid state is maintained by regulators such as transcription factors, epigenetic regulators, and phenotypic stability factors (PSFs). both computational The various EMT transition states may be governed by new factors or combinations of regulatory elements, and this is where bioinformatics approaches may excel. Despite its rarity, therapeutic intervention against hybrid E/M cells may develop as a sensible countermeasure to metastasis and drug resistance. This review has made an effort to summarize recent developments in the theory and regulation of the hybrid EMT process that results in hybrid E/M phenotypes, evidence of intermediate EMT in preclinical and clinical settings, the effect of partial EMT on promoting tumorigenesis, and potential future approaches that could be used to address this issue.
Keywords: collective migration; epithelial/mesenchymal phenotype; phenotypic stability factor;
hybrid/partial EMT; metastasis; stemness
Paper Quality: SCOPUS / Web of Science Level Research Paper
Subject: Biomolecules
Writer Experience: 20+ Years
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